Recognition-mediated regiocontrol of a dipolar cycloaddition reaction

被引：60

作者：

Howell, SJ

Spencer, N

Philp, D ^{[1
]}

机构：

[1] Univ St Andrews, Sch Chem, Ctr Biomol Sci, St Andrews KY16 9ST, Fife, Scotland

[2] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

来源：

TETRAHEDRON | 2001年 / 57卷 / 23期

基金：

英国工程与自然科学研究理事会;

关键词：

azides; cycloaddition; kinetics; molecular recognition;

D O I：

10.1016/S0040-4020(01)00402-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The rational design of a recognition-based system that is capable of accelerating and controlling the regiochemical outcome of a dipolar cycloaddition reaction between an azide and an alkyne is presented. The origins of the acceleration and control of the cycloaddition reactions are rationalized-using molecular mechanics calculations-in terms of the formation of a complex between the reagents which organizes and orients them prior to reaction. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4945 / 4954

页数：10

共 42 条

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