Murine γδ T cells in infections:: beneficial or deleterious?

被引：22

作者：

Andrew, EM ^{[1
]}

Carding, SR ^{[1
]}

机构：

[1] Univ Leeds, Sch Biochem & Microbiol, Leeds LS2 9JT, W Yorkshire, England

来源：

MICROBES AND INFECTION | 2005年 / 7卷 / 03期

关键词：

T cells; infections; T cell receptors; inflammation;

D O I：

10.1016/j.micinf.2004.12.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although the importance of gamma delta T cells in pathogen-induced immune responses is becoming increasingly apparent, it is not clear that their involvement is always of benefit to the host. Here we review evidence for the protective and damaging roles of gamma delta T cells in infection and discuss how these disparate findings might be resolved by considering the nature and properties of the pathogen, the sites of infection and conditions under which gamma delta T cell responses are initiated, and the involvement of different subsets of gamma delta T cells. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：529 / 536

页数：8

共 70 条

[1]

Belles C, 1996, J IMMUNOL, V156, P4280

[2] An innate view of gamma delta T cells [J].

Boismenu, R ;

Havran, WL .

CURRENT OPINION IN IMMUNOLOGY, 1997, 9 (01) :57-63

[3]

Born W, 1999, Adv Immunol, V71, P77

[4] Comparison of pathogenesis and host immune responses to Candida glabrata and Candida albicans in systemically infected immunocompetent mice [J].

Brieland, J ;

Essig, D ;

Jackson, C ;

Frank, D ;

Loebenberg, D ;

Menzel, F ;

Arnold, B ;

DiDomenico, B ;

Hare, R .

INFECTION AND IMMUNITY, 2001, 69 (08) :5046-5055

[5] γδ T cells:: Functional plasticity and heterogeneity [J].

Carding, SR ;

Egan, PJ .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (05) :336-345

[6] ACTIVATION OF CYTOKINE GENES IN T-CELLS DURING PRIMARY AND SECONDARY MURINE INFLUENZA PNEUMONIA [J].

CARDING, SR ;

ALLAN, W ;

MCMICKLE, A ;

DOHERTY, PC .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (02) :475-482

[7] γ/δ T cell-deficient mice exhibit reduced disease severity and decreased inflammatory response in the brain in murine neurocysticercosis [J].

Cardona, AE ;

Teale, JM .

JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3163-3171

[8] CC chemokines mediate leukocyte trafficking into the central nervous system during murine neurocysticercosis:: Role of γδ T cells in amplification of the host immune response [J].

Cardona, AE ;

Gonzalez, PA ;

Teale, JM .

INFECTION AND IMMUNITY, 2003, 71 (05) :2634-2642

[9] Immunity to blood-stage murine malarial parasites is MHC class II dependent [J].

Cigel, F ;

Batchelder, J ;

Burns, JM ;

Yañez, D ;

van der Heyde, H ;

Manning, DD ;

Weidanz, WP .

IMMUNOLOGY LETTERS, 2003, 89 (2-3) :243-249

[10]

DSouza CD, 1997, J IMMUNOL, V158, P1217

← 1 2 3 4 5 6 7 →