Vitamin C supplementation affects oxidative-stress blood markers in response to a 30-minute run at 75% VO2max

被引：47

作者：

Goldfarb, AH ^{[1
]}

Patrick, SW ^{[1
]}

Bryer, S ^{[1
]}

You, TJ ^{[1
]}

机构：

[1] Univ N Carolina, Dept Exercise & Sport Sci, Greensboro, NC 27402 USA

来源：

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM | 2005年 / 15卷 / 03期

关键词：

antioxidants; ascorbic acid; oxidative stress; glutathione;

D O I：

10.1123/ijsnem.15.3.279

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Vitamin C supplementation (VC) (either 500 or 1000 mg/d for 2 wk) was compared to a placebo treatment (P) to ascertain if VC could influence oxidative stress. Twelve healthy males (25 +/- 1.4 y) were randomly assigned in a counter-balanced design with a 2-wk period between treatments. Data were analyzed using repeated measures ANOVA. Exercise intensity measures (VO2, RER, RPE, HR, lactate) were similar across treatments. Resting blood oxidative-stress markers were unaffected by treatment. Exercise decreased total blood glutathione (TGSH) and reduced glutathione (GSH) and increased oxidized glutathione (GSSG) (P < 0.01) independent of treatment. Protein carbonyls (PC) increased 3.8 fold in the P (P < 0.01). VC attenuated the PC exercise response in a dose-dependent manner (P < 0.01). Thiobarbituric acid reactive substances (TBARS) was not influenced by exercise (P = 0.68) or VC. These data suggest that VC supplementation can attenuate exercise-induced protein oxidation in a dose-dependent manner with no effect on lipid peroxidation and glutathione status.

引用

页码：279 / 290

页数：12

共 33 条

[1]

Alessio HM, 1997, INT J SPORT NUTR, V7, P1

[2]

ANDERSON ME, 1985, METHOD ENZYMOL, V113, P548

[3] Electron spin resonance spectroscopy, exercise, and oxidative stress: an ascorbic acid intervention study [J].

Ashton, T ;

Young, IS ;

Peters, JR ;

Jones, E ;

Jackson, SK ;

Davies, B ;

Rowlands, CC .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 87 (06) :2032-2036

[4]

Bazzarre T L, 1983, Nutr Cancer, V5, P201, DOI 10.1080/01635588309513797

[5] CELLULAR PRODUCTION OF HYDROGEN-PEROXIDE [J].

BOVERIS, A ;

CHANCE, B ;

OSHINO, N .

BIOCHEMICAL JOURNAL, 1972, 128 (03) :617-&

[6] Effect of exercise during the follicular and luteal phases on indices of oxidative stress in healthy women [J].

Chung, SC ;

Goldfarb, AH ;

Jamurtas, AZ ;

Hegde, SS ;

Lee, J .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1999, 31 (03) :409-413

[7] CALCULATION OF PERCENTAGE CHANGES IN VOLUMES OF BLOOD, PLASMA, AND RED-CELLS IN DEHYDRATION [J].

DILL, DB ;

COSTILL, DL .

JOURNAL OF APPLIED PHYSIOLOGY, 1974, 37 (02) :247-248

[8] ASCORBATE IS AN OUTSTANDING ANTIOXIDANT IN HUMAN-BLOOD PLASMA [J].

FREI, B ;

ENGLAND, L ;

AMES, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (16) :6377-6381

[9] ANTIOXIDANT DEFENSES AND LIPID-PEROXIDATION IN HUMAN-BLOOD PLASMA [J].

FREI, B ;

STOCKER, R ;

AMES, BN .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (24) :9748-9752

[10] VITAMIN-E-DEFICIENCY AND VITAMIN-C SUPPLEMENTS - EXERCISE AND MITOCHONDRIAL OXIDATION [J].

GOHIL, K ;

PACKER, L ;

DELUMEN, B ;

BROOKS, GA ;

TERBLANCHE, SE .

JOURNAL OF APPLIED PHYSIOLOGY, 1986, 60 (06) :1986-1991

← 1 2 3 4 →