DNA structure checkpoint pathways in Schizosaccharomyces pombe

被引：78

作者：

Caspari, T ^{[1
]}

Carr, AM ^{[1
]}

机构：

[1] Univ Sussex, MRC, Cell Mutat Unit, Brighton BN1 9RR, E Sussex, England

来源：

BIOCHIMIE | 1999年 / 81卷 / 1-2期

关键词：

checkpoint; DNA replication; DNA damage; mitosis; Schizosaccharomyces pombe;

D O I：

10.1016/S0300-9084(99)80050-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The response to DNA damage includes a delay to progression through the cell cycle to aid DNA repair Incorrectly replicated chromosomes (replication checkpoint) or DNA damage (DNA damage checkpoint) delay the onset of mitosis. These checkpoint pathways detect DNA perturbations and generate a signal. The signal is amplified and transmitted to the cell cycle machinery. Since the checkpoint pathways are essential for genome stability, the related proteins which are found in all eukaryotes (from yeast to mammals) are expected to have similar functions to the yeast progenitors. This review article focuses on the function of checkpoint proteins in the model system Schizosaccharomyces pombe. Checkpoint controls in Saccharomyces cerevisiae and mammalian cells are mentioned briefly to underscore common or diverse features. (C) Societe francaise de biochimie et biologie moleculaire / Elsevier, Paris.

引用

页码：173 / 181

页数：9

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