Rolling circle amplification for scoring single nucleotide polymorphisms

被引：8

作者：

Rösler, A

Bailey, L

Jones, S

Briggs, J

Cuss, S

Horsey, I

Kenrick, M

Kingsmore, S

Kent, L

Pickering, J

Knott, T

Shipstone, E

Scozzafava, G

机构：

[1] Amersham Pharmacia Bioltech UK Ltd, Little Chalfont, Bucks, England

[2] Mol Staging Inc, Guilford, CT USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期

关键词：

D O I：

10.1081/NCN-100002453

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The analysis of the genetic basis of phenotypic traits is moving towards the complex diseases prevalent in wealthy populations. There is an increasing requirement for the detection of different types of sequence variation, particularly single-nucleotide polymorphisms (SNPs). SNPs occur about once every 100 to 300 bases. High-density SNP maps will help to identify the multiple genes associated with complex diseases such as cancer, diabetes, vascular disease, and some forms of mental illness.

引用

页码：893 / 894

页数：2