学术探索
学术期刊
新闻热点
数据分析
智能评审

Lactonamycin, a new antimicrobial antibiotic produced by streptomyces rishiriensis MJ773-88K4 II. Structure determination

被引：49
作者：
Matsumoto, N
Tsuchida, T
Nakamura, H
Sawa, R
Takahashi, Y
Naganawa, H
Iinuma, H
Sawa, T
Takeuchi, T
Shiro, M
机构：
[1] Inst Microbial Chem, Shinagawa Ku, Tokyo 1410021, Japan
[2] Rigaku Corp, Akishima, Tokyo 1968666, Japan
来源：
JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 03期
关键词：
D O I：
10.7164/antibiotics.52.276
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The absolute structure of a new antibiotic lactonamycin is described. The NMR studies deduced one of four possible structures for the aglycon attached by a rhodinose through glycosidic bond. The stereochemistry of the sugar obtained by an acid hydrolysis was determined to be L-form by measuring optical rotation. The stereochemistry of the aglycon was determined by X-ray crystallographic analysis.
引用
收藏
页码：276 / 280
页数：5
相关论文
共 6 条
[1]   SIR92 - a program for automatic solution of crystal structures by direct methods [J].
ALTOMARE, A ;
CASCARANO, G ;
GIACOVAZZO, G ;
GUAGLIARDI, A ;
BURLA, MC ;
POLIDORI, G ;
CAMALLI, M .
JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1994, 27 :435-435
[2]  
Beurskens P. T., 1994, DIRDIF 94 PROGRAM SY
[3]   RHODINOSE, EINE TRIDESOXY-HEXOSE [J].
BROCKMANN, H ;
WAEHNELDT, T .
NATURWISSENSCHAFTEN, 1963, 50 (02) :43-&
[4]   STUDIES ON THE CONSTITUENTS OF VIBURNUM SPECIES .7. GAMMA-LACTONE GLYCOSIDES FROM THE LEAVES OF VIBURNUM-WRIGHTII-MIQ [J].
MACHIDA, K ;
KIKUCHI, M .
CHEMICAL & PHARMACEUTICAL BULLETIN, 1994, 42 (07) :1388-1392
[5]   Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis MJ773-88K4 I.: Taxonomy, fermentation, isolation, physico-chemical properties and biological activities [J].
Matsumoto, N ;
Tsuchida, T ;
Maruyama, M ;
Kinoshita, N ;
Homma, Y ;
Iinuma, H ;
Sawa, T ;
Hamada, M ;
Takeuchi, T ;
Heida, N ;
Yoshioka, T .
JOURNAL OF ANTIBIOTICS, 1999, 52 (03) :269-275
[6]   Lactonamycin, a new antimicrobial antibiotic produced by Streptomyces rishiriensis [J].
Matsumoto, N ;
Tsuchida, T ;
Maruyama, M ;
Sawa, R ;
Kinoshita, N ;
Homma, Y ;
Takahashi, Y ;
Iinuma, H ;
Naganawa, H ;
Sawa, T ;
Hamada, M ;
Takeuchi, T .
JOURNAL OF ANTIBIOTICS, 1996, 49 (09) :953-954
1