Relation between 1H MR spectroscopic imaging and regional cerebral glucose metabolism in Alzheimer's disease

被引：18

作者：

Mielke, R

Schopphoff, HH

Kugel, H

Pietrzyk, U

Heindel, W

Kessler, J

Heiss, WD

机构：

[1] Max Planck Inst Neurol Res, D-50931 Cologne, Germany

[2] Univ Cologne, Dept Radiol, D-5000 Cologne 41, Germany

[3] Univ Munster, Dept Clin Radiol, D-4400 Munster, Germany

来源：

INTERNATIONAL JOURNAL OF NEUROSCIENCE | 2001年 / 107卷 / 3-4期

关键词：

Alzheimer's disease; emission computed tomography; magnetic resonance spectroscopic imaging; cerebral glucose metabolism; N-acetyl aspartate; choline;

D O I：

10.3109/00207450109150687

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

H-1 Magnetic resonance spectroscopic imaging (MRSI) and positron emission tomograph): (PET) of F-18-2-Ruoro-2-deoxy-D-glucose (FDG) were performed in 18 patients with probable Alzheimer's disease (AD) and 3 normal controls, We measured the distribution and relative signal intensities of N-acetyl aspartate (NAA; a presumed neuronal marker:,: choline residues (Cho) representing cellular membrane compounds and of creatine-containing metabolites (Cr), and correlated these to regional cerebral glucose metabolism (rCMRGI) after coregistration of both imaging-techniques. The pattern of choline was significantly different between AD and normals (p < 0.01). RCMRGI was significantly related to Cho/Cr (r = -0.21, p < .05) and NAA:Cho quotients (r = 0.35, p < .001). Our results suggest that in AD reduced neuronal energy performance and membrane abnormalities contribute to metabolic deterioration.

引用

页码：233 / +

页数：15

共 38 条

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