DNA methylation and human disease

被引：2150

作者：

Robertson, KD ^{[1
]}

机构：

[1] Univ Florida, Shands Canc Ctr, Dept Biochem & Mol Biol, Gainesville, FL 32610 USA

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg1655

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

DNA methylation is a crucial epigenetic modification of the genome that is involved in regulating many cellular processes. These include embryonic development, transcription, chromatin structure, X chromosome inactivation, genomic imprinting and chromosome stability. Consistent with these important roles, a growing number of human diseases have been found to be associated with aberrant DNA methylation. The study of these diseases has provided new and fundamental insights into the roles that DNA methylation and other epigenetic modifications have in development and normal cellular homeostasis.

引用

页码：597 / 610

页数：14

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