Cell Membranes: The Lipid Perspective

被引：177

作者：

Coskun, Uenal ^{[1
]}

Simons, Kai ^{[1
]}

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany

来源：

STRUCTURE | 2011年 / 19卷 / 11期

关键词：

ELECTRON CRYSTALLOGRAPHY; GLYCOLIPID CONFORMATION; PROTEIN INTERACTIONS; CRYSTAL-STRUCTURE; EGF RECEPTOR; OCULAR LENS; CHOLESTEROL; MODEL; ACTIVATION; CRYSTALLIZATION;

D O I：

10.1016/j.str.2011.10.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although cell membranes are packed with proteins mingling with lipids, remarkably little is known about how proteins interact with lipids to carry out their function. Novel analytical tools are revealing the astounding diversity of lipids in membranes. The issue is now to understand the cellular functions of this complexity. In this Perspective, we focus on the interface of integral transmembrane proteins and membrane lipids in eukaryotic cells. Clarifying how proteins and lipids interact with each other will be important for unraveling membrane protein structure and function. Progress toward this goal will be promoted by increasing overlap between different fields that have so far operated without much crosstalk.

引用

页码：1543 / 1548

页数：6

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[1] Cardiolipin-based respiratory complex activation in bacteria [J].

Arias-Cartin, Rodrigo ;

Grimaldi, Stephane ;

Pommier, Janine ;

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Schaefer, Cedric ;

Arnoux, Pascal ;

Giordano, Gerard ;

Guigliarelli, Bruno ;

Magalon, Axel .

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[2] Membrane protein assembly into Nanodiscs [J].

Bayburt, Timothy H. ;

Sligar, Stephen G. .

FEBS LETTERS, 2010, 584 (09) :1721-1727

[3] Overcoming barriers to membrane protein structure determination [J].

Bill, Roslyn M. ;

Henderson, Peter J. F. ;

Iwata, So ;

Kunji, Edmund R. S. ;

Michel, Hartmut ;

Neutze, Richard ;

Newstead, Simon ;

Poolman, Bert ;

Tate, Christopher G. ;

Vogel, Horst .

NATURE BIOTECHNOLOGY, 2011, 29 (04) :335-340

[4] Lipids and the ocular lens [J].

Borchman, Douglas ;

Yappert, Marta C. .

JOURNAL OF LIPID RESEARCH, 2010, 51 (09) :2473-2488

[5] CHOLESTEROL AND THE GOLGI-APPARATUS [J].

BRETSCHER, MS ;

MUNRO, S .

SCIENCE, 1993, 261 (5126) :1280-1281

[6] Crystallizing Membrane Proteins for Structure Determination: Use of Lipidic Mesophases [J].

Caffrey, Martin .

ANNUAL REVIEW OF BIOPHYSICS, 2009, 38 :29-51

[7] High-resolution crystal structure of an engineered human β2-adrenergic G protein-coupled receptor [J].

Cherezov, Vadim ;

Rosenbaum, Daniel M. ;

Hanson, Michael A. ;

Rasmussen, Soren G. F. ;

Thian, Foon Sun ;

Kobilka, Tong Sun ;

Choi, Hee-Jung ;

Kuhn, Peter ;

Weis, William I. ;

Kobilka, Brian K. ;

Stevens, Raymond C. .

SCIENCE, 2007, 318 (5854) :1258-1265

[8] Lipidic cubic phase technologies for membrane protein structural studies [J].

Cherezov, Vadim .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 2011, 21 (04) :559-566

[9] Regulation of human EGF receptor by lipids [J].

Coskun, Unal ;

Grzybek, Michal ;

Drechsel, David ;

Simons, Kai .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (22) :9044-9048

[10] X-RAY STRUCTURE-ANALYSIS OF A MEMBRANE-PROTEIN COMPLEX - ELECTRON-DENSITY MAP AT 3A RESOLUTION AND A MODEL OF THE CHROMOPHORES OF THE PHOTOSYNTHETIC REACTION CENTER FROM RHODOPSEUDOMONAS-VIRIDIS [J].

DEISENHOFER, J ;

EPP, O ;

MIKI, K ;

HUBER, R ;

MICHEL, H .

JOURNAL OF MOLECULAR BIOLOGY, 1984, 180 (02) :385-398

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