The subapical compartment: a novel sorting centre?

被引:71
作者
van Ijzendoorn, SCD [1 ]
Hoekstra, D [1 ]
机构
[1] Univ Groningen, Dept Physiol Chem, Fac Med Sci, NL-9713 AV Groningen, Netherlands
关键词
D O I
10.1016/S0962-8924(99)01512-3
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Establishment of plasma membrane polarity involves numerous intracellular sorting events. In the past few years, it has become apparent that there is a subapical, non-Golgi compartment located in the hub of the sorting pathways involved. This 'subapical compartment', which probably consists of a heterogeneous subset of functionally distinct domains related to endosomes, contains some-well-characterized components involved in polarity-dependent sorting and targeting of proteins and lipids. This article discusses the evidence supporting the existence of such a compartment, its biogenesis and its role in cell polarity.
引用
收藏
页码:144 / 149
页数:6
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