Inhibitory constituents of Nardostachys chinensis on nitric oxide production in RAW 264.7 macrophages

被引：44

作者：

Hwang, Ji Sang ^{[1
]}

Lee, Seon A. ^{[1
]}

Hong, Seong Su ^{[1
,2
]}

Han, Xiang Hua ^{[1
]}

Lee, Chul ^{[1
]}

Lee, Dongho ^{[2
]}

Lee, Chong-Kil ^{[1
]}

Hong, Jin Tae ^{[1
]}

Kim, Youngsoo ^{[1
]}

Lee, Mi Kyeong ^{[1
]}

Hwang, Bang Yeon ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea

[2] Korea Univ, Sch Life Sci & Biotechnol, Seoul 136713, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Nardostachys chinensis; Valerianaceae; Sesquiterpenoid; Nitric oxide inhibitor; GUAIANE-TYPE; SESQUITERPENOIDS; NARDOSINONE;

D O I：

10.1016/j.bmcl.2011.10.043

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

The activity-guided fractionation of the MeOH extract of the rhizomes and roots of Nardostachys chinensis led to the isolation of two new sesquiterpenoids, narchinol B (8) and narchinol C (9), along with 10 known compounds, ursolic acid (1), nardosinone (2), pinoresinol (3), desoxo-narchinol A (4), kanshone B (5), epoxyconiferyl alcohol (6), debilon (7), 4 alpha,5-dimethyl-1,3-dioxo-1,2,3,4,4 alpha,5,6,7-octahydronaphthalene (10), p-coumaric acid (11), and isoferulic acid (12). Their structures were determined using spectroscopic techniques, which included 1D- and 2D-NMR. Among the isolates, compounds 2, 4, 5, 8 and 9 showed inhibitory activity against LPS-induced NO production with IC50 values of 4.6-21.6 mu M. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：706 / 708

页数：3

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