Vitamin D receptor gene polymorphisms in breast cancer

被引:52
作者
Buyru, N
Tezol, A
Yosunkaya-Fenerci, E
Dalay, N [1 ]
机构
[1] Istanbul Univ, Inst Oncol, Istanbul, Turkey
[2] Cerrahpasa Med Fac, Dept Med Biol, Istanbul, Turkey
关键词
breast cancer; polymorphism; VDR;
D O I
10.1038/emm.2003.72
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Breast cancer is the leading cause of cancer death among women around the world and its incidence is annually increasing. The vitamin D receptor (VDR) gene is a member of the nuclear receptor superfamily, which is expressed in breast tissue and known to modulate the rate of cell proliferation. Association between the VDR gene polymorphisms and cancer development has been suggested by several studies. However, the relationship between VDR polymorphisms and breast cancer is controversial and has not been confirmed by all studies. The purpose of this study was to investigate the genotype frequencies and association of the VDR Bsm I and Taq I polymorphisms with breast cancer in Turkish patients. In this study, 78 patients with breast cancer and 27 healthy individuals were. enrolled. The prevalence of the VDR Taq I and Bsm I alleles and the genotype frequencies in patients with breast cancer was similar to that in the normal population. Our data indicate that no significant differences exist between the patients and control subjects.
引用
收藏
页码:550 / 555
页数:6
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