Dynamic Change of Tetraspanin CD151 Membrane Protein Expression in Colorectal Cancer Patients

被引：17

作者：

Lin, Peng-Chan ^{[3
]}

Lin, Shao-Chieh ^{[1
,3
]}

Lee, Chung-Ta ^{[2
]}

Lin, Yih-Jyh ^{[1
,3
]}

Lee, Jenq-Chang ^{[1
]}

机构：

[1] Natl Cheng Kung Univ Hosp, Dept Surg, Tainan 70428, Taiwan

[2] Natl Cheng Kung Univ Hosp, Dept Pathol, Tainan 70428, Taiwan

[3] Natl Cheng Kung Univ Med Inst & Hosp, Tainan, Taiwan

来源：

CANCER INVESTIGATION | 2011年 / 29卷 / 08期

关键词：

CD151; Colorectal cancer; Hypoxia; Tetraspanin family; TRANSMEMBRANE-4; SUPERFAMILY; CLINICAL-SIGNIFICANCE; CELL-ADHESION; INTEGRIN; MOTILITY; ALPHA-3-BETA-1; ORGANIZATION; MIGRATION; KINASE; LINK;

D O I：

10.3109/07357907.2011.606251

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Purpose: Tomeasure the CD151 expression in colorectal cancer (CRC). Methods: CD151 expression was assessed in 179 CRC patients and 39 patients with hepatic liver metastasis. Results: High CD151 expression was observed in 48% of patients with early-stage CRC versus only 33% of patients with metastatic colon cancer. A higher level of tumor invasion status correlated with a decrease in CD151 expression. Metastatic stage and advanced tumor stage correlated with a decreased CD151 expression. Twenty-seven out of the 39-paired samples had high CD151 expression in liver metastasis sites. Conclusions: CD151 expression is decreased in patients with metastatic CRC.

引用

页码：542 / 547

页数：6

共 19 条

[1]

Ang J, 2004, CANCER EPIDEM BIOMAR, V13, P1717

[2]

Regulation of CD151 by Hypoxia Controls Cell Adhesion and Metastasis in Colorectal Cancer [J].

Chien, Chun-Wei ;

Lin, Shih-Chieh ;

Lai, Yen-Yu ;

Lin, Bo-Wen ;

Lin, Shao-Chieh ;

Lee, Jenq-Chang ;

Tsai, Shaw-Jenq .

CLINICAL CANCER RESEARCH, 2008, 14 (24) :8043-8051

[3]

Dissociation of the complex between CD151 and laminin-binding integrins permits migration of epithelial cells [J].

Chometon, G ;

Zhang, ZG ;

Rubinstein, E ;

Boucheix, C ;

Mauch, C ;

Aumailley, M .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (07) :983-995

[4]

Role of tetraspanins CD9 and CD151 in primary melanocyte motility [J].

García-López, MA ;

Barreiro, O ;

García-Díez, A ;

Sánchez-Madrid, F ;

Peñas, PF .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (05) :1001-1009

[5]

Gramont Aimery de, 2005, Semin Oncol, V32, P11, DOI 10.1053/j.seminoncol.2005.06.004

[6]

Hasegawa H, 1998, J IMMUNOL, V161, P3087

[7]

Clinical significance of transmembrane 4 superfamily in colon cancer [J].

Hashida, H ;

Takabayashi, A ;

Tokuhara, T ;

Hattori, N ;

Taki, T ;

Hasegawa, H ;

Satoh, S ;

Kobayashi, N ;

Yamaoka, Y ;

Miyake, M .

BRITISH JOURNAL OF CANCER, 2003, 89 (01) :158-167

[8]

Homophilic interactions of tetraspanin CD151 up-regulate motility and matrix metalloproteinase-9 expression of human melanoma cells through adhesion-dependent c-Jun activation signaling pathways [J].

Hong, In-Kee ;

Jin, Young-June ;

Byun, Hee-Jung ;

Jeoung, Doo-Il ;

Kim, Young-Myeong ;

Lee, Hansoo .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (34) :24279-24292

[9]

Overexpression of CD151 as an Adverse Marker for Intrahepatic Cholangiocarcinoma Patients [J].

Huang, Xiao-Yong ;

Ke, Ai-Wu ;

Shi, Guo-Ming ;

Ding, Zhen-Bin ;

Devbhandari, Ranjan Prasad ;

Gu, Fang-Ming ;

Li, Quan-Lin ;

Dai, Zhi ;

Zhou, Jian ;

Fan, Jia .

CANCER, 2010, 116 (23) :5440-5451

[10]

CD151 regulates epithelial cell-cell adhesion through PKC- and Cdc42-dependent actin cytoskeletal reorganization [J].

Shigeta, M ;

Sanzen, N ;

Ozawa, M ;

Gu, JG ;

Hasegawa, H ;

Sekiguchi, K .

JOURNAL OF CELL BIOLOGY, 2003, 163 (01) :165-176

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