Pathology of small cerebral arteries demonstrated by MRI: a marker of aging?

被引：2

作者：

Cottier, Jean-Philippe ^{[1
,2
,3
]}

Edjlali, Myriam ^{[1
]}

Gaillard, Marie-Agnes ^{[1
,3
]}

Domengie, Florence

Aljishi, Ali ^{[1
]}

Casals, Xavier ^{[1
]}

Herbreteau, Denis ^{[1
,3
]}

Hommet, Caroline ^{[2
,3
,4
]}

机构：

[1] CHRU Tours, Serv Neuroradiol, Tours, France

[2] UMR Inserm U930, Tours, France

[3] Univ Tours, Tours, France

[4] CHRU Tours, Serv Med Interne Geriatr, CMRR Ctr, Tours, France

来源：

GERIATRIE ET PSYCHOLOGIE NEUROPSYCHIATRIE DE VIEILLISSEMENT | 2011年 / 9卷 / 04期

关键词：

magnetic resonance imaging; cerebral angiopathy; leukoaraiosis; cerebral amyloid angiopathy; WHITE-MATTER LESIONS; SILENT BRAIN INFARCTS; GLOBAL FUNCTIONAL DECLINE; ISCHEMIC VASCULAR-DISEASE; LIFE DEPRESSIVE SYMPTOMS; INTRACEREBRAL HEMORRHAGE; COGNITIVE DECLINE; STROKE PREVENTION; ALZHEIMER-DISEASE; RISK-FACTORS;

D O I：

10.1684/pnv.2011.0301

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Brain magnetic resonance imaging frequently identifies signal abnormalities in the white matter and cerebral cortex in the elderly. They are related to a degenerative disease of the small vessels that may be of ischemic (leukoaraiosis, lacunae and infarct) or hemorrhagic (microbleeds and hematomas) origin. These lesions are part of the aging process, and compounded by vascular risk factors. They increase the occurrence frequency and severity of ischemic or hemorrhagic stroke. Their importance is also associated with the presence of cognitive and/or affective symptoms, and their impact on the occurrence and evolution of dementia remains to be evaluated. The visible consequences of this microangiopathy on MRI probably represent the focal mark of a widespread cerebrovascular disease in the brain parenchyma.

引用

页码：465 / 475

页数：11

共 55 条

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