New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster

被引：16

作者：

Anderle, Christine

Li, Shu-Ming

Kammerer, Bernd

Gust, Bertolt

Heide, Lutz

机构：

[1] Univ Tubingen, Inst Pharmazeut, D-72076 Tubingen, Germany

[2] Univ Tubingen, Inst Pharmakol & Toxikol, Klin Pharmakol, D-72076 Tubingen, Germany

来源：

JOURNAL OF ANTIBIOTICS | 2007年 / 60卷 / 08期

关键词：

antibiotics; biosynthesis; clorobiocin; ferulic acid; 3-chloro-4-hydroxycinnamic acid; Streptomyces;

D O I：

10.1038/ja.2007.64

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new aminocoumarin antibiotics, termed ferulobiocin, 3-chlorocournarobiocin and 8'-dechloro-3-chlorocournarobiocin, were isolated from the culture broth of a Streptomyces coelicolor M512 strain expressing a modified clorobiocin biosynthetic gene cluster. Structural analysis showed that these new aminocoumarins were very similar to clorobiocin, with a substituted 4-hydroxy-cinnamoyl moieties instead of the prenylated 4-hydroxy-benzoyl moiety of clorobiocin. The possible biosynthetic origin of these moieties is discussed.

引用

页码：504 / 510

页数：7

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