Unsolved mysteries in membrane traffic

被引：153

作者：

Pfeffer, Suzanne R. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 2007年 / 76卷

关键词：

golgi complex; membrane traffic; small GTPase; transport carriers;

D O I：

10.1146/annurev.biochem.76.061705.130002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Remarkable strides have been made over the past 20 years in elucidating the molecular basis of membrane trafficking (1). Indeed, a combination of biochemical and genetic approaches have determined the identity and function of many of the core constituents needed for protein secretion and endocytosis. But much remains to be learned. This review highlights underlying themes in membrane traffic to help us refocus and solve many remaining and newly emerging issues that are fundamental to mammalian cell biology and human physiology.

引用

页码：629 / 645

页数：17

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