Conjugate addition of organolithium reagents to α,β-unsaturated carboxylic acids.

被引：11

作者：

Aurell, MJ ^{[1
]}

Mestres, R ^{[1
]}

Muñoz, E ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, Valencia 46100, Spain

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 35期

关键词：

conjugate addition; carboxylic acids; organolithium;

D O I：

10.1016/S0040-4039(98)01306-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Conjugate addition of primary, secondary, tertiary alkyl and phenyl lithium reagents to 2-alkenoic acids affords good yields of branched saturated carboxylic acids. Substitution by methyl groups at the alpha-carbon strongly decreases reactivity, whereas deprotonation of the starting acid occurs almost exclusively with methyl substitution at the beta-carbon of the 2-alkenoic acid. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6351 / 6354

页数：4

共 22 条

[1] Direct easy synthesis of ketones from carboxylic acids and chlorinated compounds [J].