Key signalling nodes in mammary gland development and cancer. The Snail1-Twist1 conspiracy in malignant breast cancer progression

被引：70

作者：

Foubert, Ellen ^{[1
,2
]}

De Craene, Bram ^{[1
,2
]}

Berx, Geert ^{[1
,2
]}

机构：

[1] VIB, Dept Mol Biomed Res, Mol & Cellular Oncol Unit, B-9052 Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, B-9052 Ghent, Belgium

来源：

BREAST CANCER RESEARCH | 2010年 / 12卷 / 03期

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; NF-KAPPA-B; E-CADHERIN; TRANSCRIPTION FACTORS; TUMOR INVASION; MIR-200; FAMILY; STEM-CELLS; DOWN-REGULATION; SELF-RENEWAL; SNAIL;

D O I：

10.1186/bcr2585

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most common cancer among women, and despite significant advances in diagnosing and treating it, metastatic spread of cancer cells results in a high mortality rate. Epithelial-to-mesenchymal transition (EMT) is an embryonic program in which epithelial cells lose their characteristics and gain mesenchymal features. Therefore, EMT might play a very important role during malignant tumour progression. In this review we summarise recent advances in breast cancer research with a particular focus on the transcription factors Snail1 and Twist1. Besides discussing the role of EMT in normal mammary gland development, we describe regulatory mechanisms involving newly discovered upstream regulators and microRNAs, the association of EMT with breast cancer stem cells, and the involvement of the tumour micro-environment in breast cancer progression.

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页数：11

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