Synthesis and cytotoxicity of 5-fluorouracil/diazeniumdiolate conjugates

被引：69

作者：

Cai, TWB

Tang, XP

Nagorski, J

Brauschweiger, PG

Wang, PG ^{[1
]}

机构：

[1] Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

[3] Univ Miami, Dept Radiat Oncol, Miami, FL 33136 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 23期

关键词：

D O I：

10.1016/j.bmc.2003.09.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

5-Fluorouracil/diazeniumdiolate conjugates were first synthesized, and showed greater cytotoxicities than 5-fluorouracil for DU 145 human prostate and HeLa cancer cells. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4971 / 4975

页数：5

共 14 条

[1] Modulation of cisPlatin cytotoxicity by interleukin-1 alpha and resident tumor macrophages [J].

Braunschweiger, PG ;

Basrur, VS ;

Cameron, D ;

Sharpe, L ;

Santos, O ;

Perras, JP ;

Sevin, BU ;

Markoe, AM .

BIOTHERAPY, 1997, 10 (02) :129-137

[2] Nitric-oxide releasing molecules: A new class of drugs with several major indications [J].

Burgaud, JL ;

Riffaud, JP ;

Del Soldato, P .

CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (03) :201-213

[3] O-alkylation of cupferron: Aiming at the design and synthesis of controlled nitric oxide releasing agents [J].

Hou, YC ;

Xie, WH ;

Janczuk, AJ ;

Wang, PG .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (14) :4333-4337

[4] Chemistry of the nitric oxide-releasing diazeniumdiolate ("nitrosohydroxylamine") functional group and its oxygen-substituted derivatives [J].

Hrabie, JA ;

Keefer, LK .

CHEMICAL REVIEWS, 2002, 102 (04) :1135-1154

[5]

Ignarro L.J., 2000, NITRIC OXIDE BIOL PA

[6]

Jia QA, 2002, EXPERT OPIN THER PAT, V12, P819

[7]

Machover D, 1997, CANCER, V80, P1179, DOI 10.1002/(SICI)1097-0142(19971001)80:7<1179::AID-CNCR1>3.0.CO

[8]

2-G

[9]

Malet-Martino M., 2002, Current Medicinal Chemistry - Anti-Cancer Agents, V2, P267

[10] Clinical studies of three oral prodrugs of 5-fluorouracil (capecitabine, UFT, S-1): A review [J].

Malet-Martino, M ;

Martino, R .

ONCOLOGIST, 2002, 7 (04) :288-323

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