ABC of oral bioavailability: transporters as gatekeepers in the gut

被引：237

作者：

Dietrich, CG

Geier, A

Elferink, RPJO

机构：

[1] Univ Aachen, Dept Gastroenterol & Hepatol, Med Klin 3, D-52057 Aachen, Germany

[2] Univ Amsterdam, Acad Med Ctr, AMC Liver Ctr, NL-1105 AZ Amsterdam, Netherlands

来源：

GUT | 2003年 / 52卷 / 12期

关键词：

D O I：

10.1136/gut.52.12.1788

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

引用

页码：1788 / 1795

页数：8

共 109 条

[1]

Achira M, 1999, AAPS PHARMSCI, V1

[2] Cytochromes P450 and metabolism of xenobiotics [J].

Anzenbacher, P ;

Anzenbacherová, E .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2001, 58 (5-6) :737-747

[3] Promoter characterization and genomic organization of the human breast cancer resistance protein (ATP-binding cassette transporter G2) gene [J].

Bailey-Dell, KJ ;

Hassel, B ;

Doyle, LA ;

Ross, DD .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 2001, 1520 (03) :234-241

[4] Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions [J].

Bakos, É ;

Evers, R ;

Sinkó, E ;

Váradi, A ;

Borst, P ;

Sarkadi, B .

MOLECULAR PHARMACOLOGY, 2000, 57 (04) :760-768

[5] Effect of grapefruit juice on digoxin pharmacokinetics in humans [J].

Becquemont, L ;

Verstuyft, C ;

Kerb, R ;

Brinkmann, U ;

Lebot, M ;

Jaillon, P ;

Funck-Brentano, C .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 70 (04) :311-316

[6] SXR, a novel steroid and xenobiotic-sensing nuclear receptor [J].

Blumberg, B ;

Sabbagh, W ;

Juguilon, H ;

Bolado, J ;

van Meter, CM ;

Ono, ES ;

Evans, RM .

GENES & DEVELOPMENT, 1998, 12 (20) :3195-3205

[7] Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions [J].

Bodó, A ;

Bakos, E ;

Szeri, F ;

Váradi, A ;

Sarkadi, B .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (26) :23529-23537

[8] Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects [J].

Cascorbi, I ;

Gerloff, T ;

Johne, A ;

Meisel, C ;

Hoffmeyer, S ;

Schwab, M ;

Schaeffeler, E ;

Eichelbaum, M ;

Brinkmann, U ;

Roots, I .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :169-174

[9] Vectorial transport by double-transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2 [J].

Cui, YH ;

König, J ;

Keppler, D .

MOLECULAR PHARMACOLOGY, 2001, 60 (05) :934-943

[10] Interleukin-1β suppresses retinoid transactivation of two hepatic transporter genes involved in bile formation [J].

Denson, LA ;

Auld, KL ;

Schiek, DS ;

McClure, MH ;

Mangelsdorf, DJ ;

Karpen, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :8835-8843

← 1 2 3 4 5 6 7 8 9 10 →