Caffeine abstinence augments the systolic blood pressure response to adenosine in humans

被引：17

作者：

Rongen, GA

Brooks, SC

Ando, S

Notarius, CF

Floras, JS

机构：

[1] Univ Toronto, Mt Sinai Hosp, Div Cardiol, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Toronto Hosp, Div Cardiol, Toronto, ON M5G 1X5, Canada

[3] Univ Toronto, Cardiovasc Res Ctr, Div Cardiol, Toronto, ON M5G 1X5, Canada

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 1998年 / 81卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0002-9149(98)00177-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood pressure and heart rate responses to adenosine infusion (35, 70, and 140 mu g/kg/min, intravenously) were studied in 7 healthy men after 6, 30, 78, 150, and 318 hours of abstinence from regular caffeine use. The finding that caffeine abstinence augmented the systolic presser response (from -1 +/- 2 mm Hg at 6 hours to +9 +/- 2 mm Hg at 318 hours; p = 0.01) but not the tachycardic response to adenosine has implications for current clinical and research applications of this purine.

引用

页码：1382 / +

页数：5

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