Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling

被引：251

作者：

Ng, KL ^{[1
]}

Li, JD ^{[1
]}

Cheng, MY ^{[1
]}

Leslie, FM ^{[1
]}

Lee, AG ^{[1
]}

Zhou, QY ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA

来源：

SCIENCE | 2005年 / 308卷 / 5730期

关键词：

D O I：

10.1126/science.1112103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurogenesis persists in the olfactory bulb (OB) of the adult mammalian brain. New interneurons are continually added to the OB from the subventricular zone (SVZ) via the rostral migratory stream (RMS). Here we show that secreted prokineticin 2 (PK2) functions as a chemoattractant for SVZ-derived neuronal progenitors. Within the OB, PK2 may also act as a detachment signal for chain-migrating progenitors arriving from the RMS. PK2 deficiency in mice leads to a marked reduction in OB size, loss of normal OB architecture, and the accumulation of neuronal progenitors in the RMS. These findings define an essential role for G protein-coupled PK2 signaling in postnatal and adult OB neurogenesis.

引用

页码：1923 / 1927

页数：5

共 35 条

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