Development and validation of an LC-MS-MS method for the determination of terfenadine in human plasma

被引：17

作者：

Xu, A

Linderholm, K

Peng, L

Hulse, J

机构：

[1] Harris Laboratories, Lincoln, NE 68501

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1996年 / 14卷 / 12期

关键词：

LC-MS-MS; terfenadine; antihistamine;

D O I：

10.1016/0731-7085(96)01804-3

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A sensitive LC-MS-MS method capable of quantifying terfenadine at levels down to 100 pg ml(-1) in human plasma is reported. The method was validated over a linear range from 0.1 to 5.0 ng ml(-1) using a liquid-liquid extraction with a deuterium-labelled internal standard. The between-run precision and accuracy of the calibration standards were 2.6-6.0% RSD and -2.0 to +2.2%, relative error (RE). The between-run and within-run precision and accuracy of quality control samples (0.3, 1.5 and 3.5 ng ml(-1)) were 1.0-5.9% RSD and +1.7 to +6.3% RE. This method was applied to the analysis of human plasma samples.

引用

页码：1675 / 1680

页数：6

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