Synthesis and antiviral evaluation of 2′-deoxy-4′-thio-L-nucleosides and their phosphotriester derivatives bearing S-acyl-2-thioethyl bioreversible phosphate-protecting groups.

被引：12

作者：

De Valette, F ^{[1
]}

Barascut, JL ^{[1
]}

Imbach, JL ^{[1
]}

机构：

[1] Univ Montpellier 2, Chim Bioorgan Lab, UMR CNRS UMII 5625, F-34095 Montpellier 5, France

来源：

NUCLEOSIDES & NUCLEOTIDES | 1998年 / 17卷 / 12期

关键词：

D O I：

10.1080/07328319808004318

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new route to 2-deoxy-4-thio-L-ribofuranose and the synthesis of some 4'-thio-L-nucleosides are reported. Also, the bis(SATE) phosphotriester derivatives of 2'-deoxy-4'-thio-L-cytidine and -adenosine were synthesized and their biological activities are discussed.

引用

页码：2289 / 2310

页数：22

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