Hidden VIM-1 metallo-β-lactamase phenotypes among Acinetobacter baumannii clinical isolates

被引：20

作者：

Ikonornidis, Alexandros ^{[1
]}

Ntokou, Eleni ^{[1
]}

Maniatis, Antonios N. ^{[1
]}

Tsakris, Athanassios ^{[2
]}

Pournaras, Spyros ^{[1
]}

机构：

[1] Univ Thessaly, Sch Med, Dept Microbiol, Larisa, Greece

[2] Univ Athens, Sch Med, Dept Microbiol, GR-11527 Athens, Greece

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 01期

关键词：

D O I：

10.1128/JCM.01670-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A total of 87 Acinetobacter baumannii nonrepetitive consecutive clinical isolates were tested for the presence of metallo-beta-lactamases (MBLs). Results of phenotypic assays (MBL Etest, imipenem/imipenem-EDTA combined-disk test, and imipenem/EDTA double-disk synergy test) were negative in all cases, but molecular testing revealed the presence of two bla(VIM-1)-carrying isolates. One isolate had bla(VIM-1) preceded by a weak P1 promoter, and both had inactivated P2 promoters and reduced bla(VIM-1), expression, partially justifying the results revealing hidden MBL phenotypes.

引用

页码：346 / 349

页数：4

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