Novel triterpene sulfates from Fusarium compactum using a rhinovirus 3C protease inhibitor screen

被引：22

作者：

Brill, GM

Kati, WM

Montgomery, D

Karwowski, JP

Humphrey, PE

Jackson, M

Clement, JJ

Kadam, S

Chen, RH

McAlpine, JB

机构：

[1] New Lead Discov. Anti-infective Res., Pharmaceutical Prod. R. and D., Abbott Laboratories, Abbott Park

来源：

JOURNAL OF ANTIBIOTICS | 1996年 / 49卷 / 06期

关键词：

D O I：

10.7164/antibiotics.49.541

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two novel triterpene sulfates have been isolated from Fusarium compactum by bioactivity-directed fractionation using an assay which measures the inhibition of proteolytic activity of rhinovirus 3C protease on a fluorogenic peptide substrate. The compounds were purified by countercurrent and reverse phase chromatographies. NMR, MS, UV and IR studies revealed two triterpene sulfates, uncommon metabolites of terrestrial fungi.

引用

页码：541 / 546

页数：6

共 11 条

[1] PRODUCTION OF A NOVEL STEROID SULFATE METABOLITE [4,4,24-TRIMETHYLCHOLESTA-8,14,24(28)-TRIEN-2-ALPHA,3-BETA,11-ALPHA,12-BETA-TETROL 12-ACETATE, 3-SULFATE] BY FUSARIUM SPECIES AND ITS BIOLOGICAL-ACTIVITY [J].