Hypoglycemic effect of syringin from Eleutherococcus senticosus in streptozotocin-induced diabetic rats

被引：90

作者：

Niu, Ho-Shan ^{[1
,2
]}

Liu, I-Min ^{[3
]}

Cheng, Juei-Tang

Lin, Che-Ling ^{[4
]}

Hsu, Feng-Lin ^{[1
]}

机构：

[1] Taipei Med Univ, Coll Pharm, Sch Pharm, Grad Inst Pharmacognosy, Taipei, Taiwan

[2] Jente Jr Coll Med Nursing & Management, Dept Nursing, Taipei, Taiwan

[3] Tajen Univ, Coll Environm & Hlth Sci, Dept Pharm, Ping Tung Shien, Taiwan

[4] Natl Yang Ming Univ, Inst Tradit Med, Taipei 112, Taiwan

来源：

PLANTA MEDICA | 2008年 / 74卷 / 02期

关键词：

syringin; Eleutherococcus senticosus; Araliaceae; STZ-diabetic rats; glucose uptake; glycogen synthesis;

D O I：

10.1055/s-2008-1034275

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Eleutherococcus senticosus (Araliaceae) is a very powerful adaptogenic agent. In the present study, the effects of syringin, an active principle of this herb, on plasma glucose levels in streptozotocin-induced diabetic rats (STZ-diabetic rats) were investigated. Thirty minutes after syringin was intravenously injected into fasting STZ-diabetic rats, plasma glucose levels dose-dependently decreased. In normal rats, syringin at the effective dose (1.0 mg/kg) significantly attenuated the increase in plasma glucose caused by an intravenous glucose challenge. Syringin dose-dependently (0.01 to 10.0 mu mol/L) stimulated glucose uptake in soleus muscle isolated from STZ-diabetic rats. Syringin treatment of hepatocytes isolated from STZ-diabetic rats enhanced glycogen synthesis. The ability of syringin to enhance glucose utilization and lower plasma glucose level in rats suffering from insulin deficiency suggest that this chemical may be useful in the treatment of human diabetes.

引用

页码：109 / 113

页数：5

共 17 条

[1]

ASANO K, 1986, PLANTA MED, P175, DOI 10.1055/s-2007-969114

[2]

DECREASED EXPRESSION OF THE INSULIN-RESPONSIVE GLUCOSE TRANSPORTER IN DIABETES AND FASTING [J].