Cytokines and the microcirculation in ischemia and reperfusion

被引：160

作者：

Frangogiannis, NG

Youker, KA

Rossen, RD

Gwechenberger, M

Lindsey, MH

Mendoza, LH

Michael, LH

Ballantyne, CM

Smith, CW

Entman, ML

机构：

[1] Baylor Coll Med, Dept Med, Cardiovasc Sci Sect, DeBakey Heart Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Pediat, Sect Leukocyte Biol, Houston, TX 77030 USA

[3] Vet Affairs Med Ctr, Houston, TX 77030 USA

来源：

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 1998年 / 30卷 / 12期

关键词：

cytokines; inflammation; reperfusion injury; cardiac tissue repair; leukocytes;

D O I：

10.1006/jmcc.1998.0829

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The intense inflammatory reaction following reperfusion of the infarcted myocardium has been implicated as a factor in extension of injury. However, this inflammatory reaction is also critical to tissue repair. The cellular responses that mediate these functions are orchestrated by sequential induction and/or release of cytokines resulting in a closely regulated cytokine cascade. This paper reviews research on these cytokine cascades, their cellular origin, and factors which control the cellular response to their presence. Factors examined include leukotaxis, phenotypic transition of leukocytes, adhesion molecule induction and the role of cytokines in tissue repair and scar formation. (C) 1998 Academic Press.

引用

收藏

页码：2567 / 2576

页数：10

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