PEG-ylated cationic CdSe/ZnS QDs as an efficient intracellular labeling agent

被引：43

作者：

Lee, Junghan ^{[1
]}

Kim, Junwon ^{[1
]}

Park, Eunjung ^{[1
]}

Jo, Shineun ^{[1
]}

Song, Rita ^{[1
]}

机构：

[1] Inst Pasteur Korea IP K, Nano Bio Chem Lab, Seoul 136791, South Korea

来源：

PHYSICAL CHEMISTRY CHEMICAL PHYSICS | 2008年 / 10卷 / 13期

关键词：

D O I：

10.1039/b801317a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Quantum dots (QDs) have size-tunable optical properties, such as photostability, strong photoluminescence and a large Stokes-shift, which make it possible to adapt them to various biological applications. In many cases, surface modi. cation of QDs by carboxylate ligands has been extensively studied. However, there have been few applications on QDs modified with a potential cationic ligand such as amine. In this study, we synthesized robust amine-functionalized QDs and modified their surface with poly( ethylene glycol) for long-term stability. These QDs showed an excellent stability over a broad pH-range and remarkable internalization efficiency into living cells.

引用

页码：1739 / 1742

页数：4

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