Mood disorders in the medically ill: Scientific review and recommendations

被引:838
作者
Evans, DL
Charney, DS
Lewis, L
Golden, RN
Gorman, JM
Krishnan, KRR
Nemeroff, CB
Bremner, JD
Carney, RM
Coyne, JC
Delong, MR
Frasure-Smith, N
Glassman, AH
Gold, PW
Grant, I
Gwyther, L
Ironson, G
Johnson, RL
Kanner, AM
Katon, WJ
Kaufmann, PG
Keefe, FJ
Ketter, T
Laughren, TP
Leserman, J
Lyketsos, CG
McDonald, WM
McEwen, BS
Miller, AH
Musselman, D
O'Connor, C
Petitto, JM
Pollock, BG
Robinson, RG
Roose, SP
Rowland, J
Sheline, Y
Sheps, DS
Simon, G
Spiegel, D
Stunkard, A
Sunderland, T
Tibbits, P
Valvo, WJ
机构
[1] Univ Penn, Sch Med, Dept Psychiat, Philadelphia, PA 19104 USA
[2] Washington Univ, St Louis, MO USA
[3] Emory Univ, Atlanta, GA 30322 USA
[4] NCI, NIMH, NHLBI, Bethesda, MD 20892 USA
[5] United States Food & Drug Adm, Rockville, MD USA
[6] Johns Hopkins Univ, Baltimore, MD USA
[7] Univ Pittsburgh, Pittsburgh, PA USA
[8] McGill Univ, Montreal, PQ, Canada
[9] Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada
[10] Columbia Univ, New York, NY USA
[11] Mt Sinai Sch Med, New York, NY USA
[12] Rockefeller Univ, New York, NY 10021 USA
[13] Univ N Carolina, Sch Med, Chapel Hill, NC USA
[14] Duke Univ, Durham, NC USA
[15] Stanford Univ, Stanford, CA 94305 USA
[16] Univ Calif San Diego, San Diego, CA 92103 USA
[17] Univ Miami, Coral Gables, FL 33124 USA
[18] Univ Florida, Gainesville, FL USA
[19] Univ Med & Dent New Jersey, Newark, NJ 07103 USA
[20] St Lukes Hosp, Chicago, IL USA
[21] Univ Washington, Ctr Hlth Studies, Grp Hlth Cooperat, Seattle, WA 98195 USA
[22] Univ Iowa, Iowa City, IA USA
[23] Amer Diabetes Assoc, Alexandria, VA USA
[24] Mended Hearts, Dallas, TX USA
基金
加拿大健康研究院; 美国国家卫生研究院;
关键词
mood disorders; medical comorbidity; depression; antidepressant therapy;
D O I
10.1016/j.biopsych.2005.05.001
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Objective. The purpose of this review is to assess the relationship between mood disorders and development, course, and associated morbidity and mortality of selected medical illnesses, review evidence for treatment, and determine needs in clinical practice and research. Data Sources. Data were culled from the 2002 Depression and Bipolar Support Alliance Conference proceedings and a literature review addressing prevalence, risk factors, diagnosis, and treatment. This review also considered the experience of primary and specialty care providers, policy analysts, and patient advocates. The review and recommendations reflect the expert opinion of the authors. Study Selection/Data Extraction: Reviews of epidemiology and mechanistic studies were included, as were open-label and randomized controlled trials on treatment of depression in patients with medical comorbidities. Data on study design, population, and results were extracted for review of evidence that includes tables of prevalence and pharmacological treatment. The effect of depression and bipolar disorder on selected medical comorbidities was assessed, and recommendations for practice, research, and policy were developed. Conclusions: A growing body of evidence suggests that biological mechanisms underlie a bidirectional link between mood disorders and many medical illnesses. In addition, there is evidence to suggest that mood disorders affect the course of medical illnesses. Further prospective studies are warranted.
引用
收藏
页码:175 / 189
页数:15
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