Cognitive and behavioural assessments in clinical trials: what type of measure?

被引：23

作者：

Baker, GA ^{[1
]}

Marson, AG ^{[1
]}

机构：

[1] Univ Liverpool, Dept Neurosci, Walton Ctr Neurol & Neurosurg, Liverpool L9 7LJ, Merseyside, England

来源：

EPILEPSY RESEARCH | 2001年 / 45卷 / 1-3期

关键词：

cognitive; behavioural; outcomes; clinical trials;

D O I：

10.1016/S0920-1211(01)00246-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This paper provides an overview of the types of neuropsychological and behavioural measures used in randomised controlled trials (RCTS) of antiepileptic drugs (AEDs) in patients with epilepsy. The results of previous systematic reviews are reported in respect of the methods used in clinical trials to assess cognitive and behavioural effects of AED treatment. There were 46 trials incorporating behavioural measures and 40 trials incorporating neuropsychological measures. The evidence supporting the choice of test, and their reliability, validity, and sensitivity to change was minimal. It is concluded that poor reporting of methods and a plethora of both neuropsychological and behavioural measures make it difficult to provide any meaningful comments about the effects of AED treatment. A much more standardised approach to assessing these effects is necessary. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：163 / 167

页数：5

共 8 条

[1] Commission on outcome measurement in epilepsy, 1994-1997: Final report [J].