CD28 superagonists:: Mode of action and therapeutic potential

被引：50

作者：

Hünig, T ^{[1
]}

Dennehy, K ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Virol & Immunol, D-97078 Wurzburg, Germany

来源：

IMMUNOLOGY LETTERS | 2005年 / 100卷 / 01期

关键词：

CD28; regulatory T-cells; autoimmunity; costimulation;

D O I：

10.1016/j.imlet.2005.06.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Some CD28-specific monoclonal antibodies (mAbs) have the surprising property to activate T-cells without the need for TCR ligation. This review summarizes the differences between these "superagonistic" and conventional CD28-specific mAbs with regard to binding specificity and signalling properties. Futhermore, the dramatic effects of in vivo application of CD28 superagonists with regard to the induction of regulatory T-cells and polyclonal T-cell expansion in lymphopenic settings are discussed under the aspect of potential therapeutic applications. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：21 / 28

页数：8

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