Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphe serotonergic neurons

被引：64

作者：

Celada, P ^{[1
]}

Siuciak, JA ^{[1
]}

Tran, TM ^{[1
]}

Altar, CA ^{[1
]}

Tepper, JM ^{[1
]}

机构：

[1] REGENERON PHARMACEUT, TARRYTOWN, NY 10536 USA

来源：

BRAIN RESEARCH | 1996年 / 712卷 / 02期

关键词：

brain-derived neurotrophic factor; BDNF; growth factor; serotonin; firing pattern;

D O I：

10.1016/0006-8993(95)01469-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies have reported a neuromodulatory effect of brain-derived neurotrophic factor (BDNF) on serotonin neurons in the central nervous system. In the present study, we examined the effects of local infusion of BDNF on the electrophysiological activity of serotonergic neurons in the rat dorsal raphe nucleus with extracellular single unit recording in vivo. Compared with vehicle-infused rats, chronic administration of BDNF (10-14 days) caused serotonergic neurons to fire in a significantly less regular pattern, without altering the mean firing rate or other measures of electrical activity. These results suggest that the ability of similar infusions of BDNF to produce behavioral effects (i.e. analgesia and an antidepressant-like effect) associated with elevated serotonin turnover may be in part the result of more irregular firing patterns of dorsal raphe neurons.

引用

页码：293 / 298

页数：6

共 46 条

[1] SEROTONERGIC AND NON-SEROTONERGIC NEURONS OF DORSAL RAPHE - RECIPROCAL CHANGES IN FIRING INDUCED BY PERIPHERAL-NERVE STIMULATION [J].