Imaging of apoptosis in the heart with nanoparticle technology

被引：16

作者：

Chen, Howard H. ^{[1
]}

Josephson, Lee ^{[1
,2
]}

Sosnovik, David E. ^{[1
,3
,4
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Mol Imaging Res, Charlestown, MA USA

[2] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Translat Nucl Med & Mol Imaging, Charlestown, MA USA

[3] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Martinos Ctr Biomed Imaging, Charlestown, MA USA

[4] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Div Cardiol, Charlestown, MA USA

来源：

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY | 2011年 / 3卷 / 01期

基金：

美国国家科学基金会;

关键词：

ACUTE MYOCARDIAL-INFARCTION; TARGETED CONTRAST AGENT; IRON-OXIDE PARTICLES; PLASMA ANNEXIN-V; NONINVASIVE DETECTION; IN-VIVO; CELL-DEATH; MAGNETIC NANOPARTICLES; ATHEROSCLEROSIS; MEMBRANE;

D O I：

10.1002/wnan.115

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Apoptosis plays an important role in the loss of cardiomyocytes in both ischemic injury and heart failure. Pioneering work with single photon emission computed tomography imaging of Tc-99-annexin showed that cell death in the heart could be imaged in vivo. Over the last 5 years a significant amount of experience with annexin-labeled magnetic nanoparticles, principally AnxCLIO-Cy5.5, has also been gained. Here, we review the experience with AnxCLIO-Cy5.5 in the heart and compare this experience to that of earlier studies with Tc-99-annexin. The imaging of apoptosis with AnxCLIO-Cy5.5 provides valuable insights not only into molecular imaging in the heart but, more broadly, into the use of nanoparticle technology for molecular imaging in general. (C) 2010 John Wiley & Sons, Inc. WIREs Nanomed Nanobiotechnol 2011 3 86-99 DOI: 10.1002/wnan.115

引用

页码：86 / 99

页数：14

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