TGFB1 polymorphisms are associated with risk of late normal tissue complications in the breast after radiotherapy for early breast cancer

被引：114

作者：

Andreassen, CN ^{[1
]}

Alsner, J

Overgaard, J

Herskind, C

Haviland, J

Owen, R

Homewood, J

Bliss, J

Yarnold, J

机构：

[1] Aarhus Univ Hosp, Dept Expt Clin Oncol, Aarhus, Denmark

[2] Univ Hosp Mannheim, Dept Radiat Oncol, Mannheim, Germany

[3] Inst Canc Res, Sect Clin Trials, Clin Trials & Stat Unit, Sutton, Surrey, England

[4] Gloucestershire Oncol Ctr, Cheltenham, Glos, England

[5] Inst Canc Res, Sect Radiotherapy, Sutton, Surrey, England

来源：

RADIOTHERAPY AND ONCOLOGY | 2005年 / 75卷 / 01期

关键词：

normal tissue complications; radiotherapy; single nucleotide polymorphisms; transforming growth factor beta 1;

D O I：

10.1016/j.radonc.2004.12.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies suggest that normal tissue radiosensitivity is influenced by single nucleotide polymorphisms (SNPs) in certain genes. In order to seek a confirmation of these findings, this study investigated SNPs in genes TGFB1 (position - 509, codon 10 and codon 25), SOD2 (codon 16), XRCC1 (codon 399), XRCC3 (codon 241), APEX (codon 148) and ATM (codon 1853) in 26 breast cancer patients with marked changes in breast appearance after radiotherapy and 26 matched controls. Statistically significant associations were found between the TGFB1 codon 10 Pro allele (P = 0.005) as welt as the TGFB1 position -509 T allele (P = 0.018) and increased risk of altered breast appearance. No significant associations were found for the remaining SNPs. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

引用

页码：18 / 21

页数：4

共 18 条

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