Fingerprinting of glycans as their 2-aminoacridone derivatives by capillary electrophoresis and laser-induced fluorescence

被引:21
作者
Harland, GB
Okafo, G
Matejtschuk, P
Sellick, IC
Chapman, GE
Camilleri, P
机构
[1] SMITHKLINE BEECHAM PHARMACEUT,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND
[2] BIOPROD LAB,ELSTREE,HERTS,ENGLAND
关键词
glycans; fetuin; monoclonal antibodies; capillary electrophoresis; 2-aminoacridone;
D O I
10.1002/elps.1150170220
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Capillary electrophoresis and laser-induced fluorescence detection have been used to fingerprint the 2-aminoacridone derivatives of complex glycans released from bovine fetuin and human IgG monoclonal antibodies. The utility of this method in distinguishing between N- and O-linked oligosaccharides and in determining the presence of sialic acid residues in glycan mixtures at an early stage of analysis has been demonstrated.
引用
收藏
页码:406 / 411
页数:6
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