In Vivo Efficacy of Anidulafungin against Mature Candida albicans Biofilms in a Novel Rat Model of Catheter-Associated Candidiasis

被引：57

作者：

Kucharikova, Sona ^{[2
,4
]}

Tournu, Helene ^{[4
]}

Holtappels, Michelle ^{[4
]}

Van Dijck, Patrick ^{[1
,4
]}

Lagrou, Katrien ^{[3
]}

机构：

[1] Katholieke Univ Leuven VIB, Mol Cell Biol Lab, Dept Mol Microbiol, B-3001 Louvain, Belgium

[2] Comenius Univ, Dept Microbiol & Virol, Bratislava, Slovakia

[3] Katholieke Univ Leuven, Dept Med Diagnost Sci, Louvain, Belgium

[4] Katholieke Univ Leuven, Inst Bot & Microbiol, Mol Cell Biol Lab, Louvain, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 10期

关键词：

CASPOFUNGIN; INFECTION;

D O I：

10.1128/AAC.00697-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The present study demonstrates the efficacy of anidulafungin on mature Candida albicans biofilms in vivo. One hundred fifty-seven catheter fragments challenged with C. albicans were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature C. albicans biofilms.

引用

页码：4474 / 4475

页数：2

共 11 条

[1] Development and characterization of an in vivo central venous catheter Candida albicans biofilm model [J].

Andes, D ;

Nett, J ;

Oschel, P ;

Albrecht, R ;

Marchillo, K ;

Pitula, A .

INFECTION AND IMMUNITY, 2004, 72 (10) :6023-6031

[2] Paradoxical growth effects of the echinocandins caspofungin and micafungin, but not of anidulafungin, on clinical isolates of Candida albicans and C-dubliniensis [J].

Fleischhacker, M. ;

Radecke, C. ;

Schulz, B. ;

Ruhnke, M. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2008, 27 (02) :127-131

[3] ISOLATION OF THE CANDIDA-ALBICANS GENE FOR OROTIDINE-5'-PHOSPHATE DECARBOXYLASE BY COMPLEMENTATION OF S-CEREVISIAE URA3 AND ESCHERICHIA-COLI PYRF MUTATIONS [J].

GILLUM, AM ;

TSAY, EYH ;

KIRSCH, DR .

MOLECULAR & GENERAL GENETICS, 1984, 198 (01) :179-182

[4] Treatment and prevention of Candida albicans biofilms with caspofungin in a novel central venous catheter murine model of candidiasis [J].

Lazzell, Anna L. ;

Chaturvedi, Ashok K. ;

Pierce, Christopher G. ;

Prasad, Deepthi ;

Uppuluri, Priya ;

Lopez-Ribot, Jose L. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2009, 64 (03) :567-570

[5]

Mermel LA, 2001, CLIN INFECT DIS, V32, P1249, DOI 10.1086/320001

[6] Role of Fks1p and Matrix Glucan in Candida albicans Biofilm Resistance to an Echinocandin, Pyrimidine, and Polyene [J].

Nett, Jeniel E. ;

Crawford, Kyler ;

Marchillo, Karen ;

Andes, David R. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (08) :3505-3508

[7] Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms [J].

Ramage, G ;

vande Walle, K ;

Wickes, BL ;

López-Ribot, JL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (09) :2475-2479

[8] Candida albicans biofilm formation in a new in vivo rat model [J].

Ricicova, Marketa ;

Kucharikova, Sona ;

Tournu, Helene ;

Hendrix, Jelle ;

Bujdakova, Helena ;

Van Eldere, Johan ;

Lagrou, Katrien ;

Van Dijck, Patrick .

MICROBIOLOGY-SGM, 2010, 156 :909-919

[9] Rabbit model of Candida albicans biofilm infection:: Liposomal amphotericin B antifungal lock therapy [J].

Schinabeck, MK ;

Long, LA ;

Hossain, MA ;

Chandra, J ;

Mukherjee, PK ;

Mohamed, S ;

Ghannoum, MA .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (05) :1727-1732

[10] Evaluation of caspofungin and amphotericin B deoxycholate against Candida albicans biofilms in an experimental intravascular catheter infection model [J].

Shuford, Jennifer A. ;

Rouse, Mark S. ;

Piper, Kerryl E. ;

Steckelberg, James M. ;

Patel, Robin .

JOURNAL OF INFECTIOUS DISEASES, 2006, 194 (05) :710-713

← 1 2 →