Use of protein-interaction maps to formulate biological questions

被引：8

作者：

Boulton, SJ

Vincent, S

Vidal, M

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA

[3] MGH Canc Ctr, Oncol Mol Lab, Charlestown, MA 02129 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2001年 / 5卷 / 01期

关键词：

D O I：

10.1016/S1367-5931(00)00168-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Protein-interaction mapping approaches generate functional information for large numbers of genes that are predicted from complete genome sequences. This information, released as databases available on the Internet, is likely to transform the way biologists formulate and then address their questions of interest.

引用

收藏

页码：57 / 62

页数：6

相关论文

共 38 条

[1] A protein linkage map of Escherichia coli bacteriophage T7 [J].

Bartel, PL ;

Roecklein, JA ;

SenGupta, D ;

Fields, S .

NATURE GENETICS, 1996, 12 (01) :72-77

[2] Transdominant genetic analysis of a growth control pathway [J].

Caponigro, G ;

Abedi, MR ;

Hurlburt, AP ;

Maxfield, A ;

Judd, W ;

Kamb, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (13) :7508-7513

[3]

Clegg Robert M., 1995, Current Opinion in Biotechnology, V6, P103, DOI 10.1016/0958-1669(95)80016-6

[4] Mapping interactions between nuclear transport factors in living cells reveals pathways through the nuclear pore complex [J].

Damelin, M ;

Silver, PA .

MOLECULAR CELL, 2000, 5 (01) :133-140

[5] The FHA domain is a modular phosphopeptide recognition motif [J].

Durocher, D ;

Henckel, J ;

Fersht, AR ;

Jackson, SP .

MOLECULAR CELL, 1999, 4 (03) :387-394

[6] A green fluorescent protein-based reverse two-hybrid system: Application to the characterization of large numbers of potential protein-protein interactions [J].

Endoh, H ;

Walhout, AJM ;

Vidal, M .

APPLICATIONS OF CHIMERIC GENES AND HYBRID PROTEINS, PT C: PROTEIN-PROTEIN INTERACTIONS AND GENOMICS, 2000, 328 :74-88

[7] Functional genomic analysis of C-elegans chromosome I by systematic RNA interference [J].

Fraser, AG ;

Kamath, RS ;

Zipperlen, P ;

Martinez-Campos, M ;

Sohrmann, M ;

Ahringer, J .

NATURE, 2000, 408 (6810) :325-330

[8]

FROMONTRACINE M, 2000, COMP FUNCTIONAL GENO, V17, P95

[9] Mutagenesis by peptide aptamers identifies genetic network members and pathway connections [J].

Geyer, CR ;

Colman-Lerner, A ;

Brent, R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (15) :8567-8572

[10] Functional genomic analysis of cell division in C-elegans using RNAi of genes on chromosome III [J].

Gönczy, P ;

Echeverri, C ;

Oegema, K ;

Coulson, A ;

Jones, SJM ;

Copley, RR ;

Duperon, J ;

Oegema, J ;

Brehm, M ;

Cassin, E ;

Hannak, E ;

Kirkham, M ;

Pichler, S ;

Flohrs, K ;

Goessen, A ;

Leidel, S ;

Alleaume, AM ;

Martin, C ;

Özlü, N ;

Bork, P ;

Hyman, AA .

NATURE, 2000, 408 (6810) :331-336

← 1 2 3 4 →