Bicyclo[2.2-1]heptanes as novel triple re-uptake inhibitors for the treatment of depression

被引：14

作者：

Axford, L

Boot, JR

Hotten, TM

Keenan, M

Martin, FM

Milutinovic, S

Moore, NA

O'Neill, MF

Pullar, IA

Tupper, DF

Van Belle, KR

Vivien, V

机构：

[1] Lilly Res Ctr Ltd, Windlesham GU20 6PH, Surrey, England

[2] Lilly Dev Ctr SA, B-1348 Mont St Guibert, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(03)00660-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of substituted naphthyl containing chiral [2.2.1] bicycloheptanes were prepared utilizing asymmetric Diels-Alder chemistry. This paper describes structure-activity relationships in this series. The N-methyl 2-naphthyl analogue (16d) and its desmethyl analogue (17d) are active triple re-uptake inhibitors both in vivo and in vitro. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：3277 / 3280

页数：4

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