Identification of hypoxia-inducible factor-Iα (HIF-Iα) polymorphism as a mutation in prostate cancer that prevents normoxia-induced degradation

被引：92

作者：

Fu, XYS ^{[1
]}

Choi, E ^{[1
]}

Bubley, GJ ^{[1
]}

Balk, SP ^{[1
]}

机构：

[1] Harvard Univ, Div Hematol Oncol, Sch Med, Div Hematol Oncol,Canc Biol Program, Boston, MA 02215 USA

来源：

PROSTATE | 2005年 / 63卷 / 03期

关键词：

von Hippel-Lindau; oxygen-dependent domain; proline hydroxylase; polymorphism; tumor susceptibility;

D O I：

10.1002/pros.20190

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

BACKGROUND. Hypoxia-inducible factor-1 alpha (HIF-1 alpha) regulates cellular responses to hypoxia and is rapidly degraded under normoxia through von Hippel-Lindau (VHL) mediated ubiquitination. Although HIF-1 alpha. stabilization appears to be the molecular basis for VHL-associated cancers, stabilizing mutations in HIF-1 alpha have not been reported.

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页码：215 / 221

页数：7

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