Gestation-induced cell proliferation in the rat brain

被引:87
作者
Furuta, M [1 ]
Bridges, RS [1 ]
机构
[1] Tufts Univ, Sch Vet Med, Dept Biomed Sci, North Grafton, MA 01536 USA
来源
DEVELOPMENTAL BRAIN RESEARCH | 2005年 / 156卷 / 01期
关键词
development and regeneration; genesis of neuron and glia; neurogenesis; pregnancy; subventricular zone;
D O I
10.1016/j.devbrainres.2005.01.008
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The states of pregnancy and lactation bring about a range of physiological and behavioral changes in the adult mammal that prepare the mother to care for her young. In the present study, the effects of pregnancy on cell proliferation in the subventricular zone (SVZ) in female rats were examined. This region has been identified as a site of neurogenesis in adult rodents. To examine the proliferating cell population, control and pregnant rats, were injected with bromodeoxyuridine (BrdU, 90 mg/kg, i.v.) and euthanized 1 h following injection. BrdU was visualized using diaminobenzidine. Changes in BrdU-labeled cells occurred in the female rat brain over pregnancy with significant increases found in the SVZ on day 21 when compared with cycling diestrous females. No changes were evident in the dentate gyrus of the hippocampus as a function of gestation. These data demonstrate that, in the rat, as in mice, gestation stimulates an increase ill the number of new cells in selected regions of the central nervous system. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:61 / 66
页数:6
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