Detection of recurrent or persistent nasopharyngeal carcinomas after radiotherapy with 18-fluoro-2-deoxyglucose positron emission tomography and comparison with computed tomography

被引:87
作者
Kao, CH
ChangLai, SP
Chieng, PU
Yen, RF
Yen, TC
机构
[1] Natl Taiwan Univ Hosp, Dept Nucl Med, Chung Shan Med & Dent Coll Hosp, Taichung Vet Gen Hosp, Taichung 40705, Taiwan
[2] Taichung Vet Gen Hosp, Dept Nucl Med, Taichung 40705, Taiwan
[3] Chung Shan Med & Dent Coll Hosp, Dept Nucl Med, Taichung, Taiwan
[4] Natl Taiwan Univ Hosp, Dept Nucl Med, Taipei, Taiwan
关键词
D O I
10.1200/JCO.1998.16.11.3550
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: The effectiveness of positron emission tomography (PET) with 18-fluoro-2-deoxyglucose (FDG) for detecting suspected recurrence of nasopharyngeal carcinomas (NPC) was evaluated and compared with computed tomography (CT). Patients and Methods: FDG-PET studies were performed on 36 NPC patients 4 months after radiotherapy. The images were interpreted visually and quantitatively by calculating standardized uptake values (SUVs), Results: The sensitivity, specificity, and accuracy of visually interpreted FDG-PET images, for differentiation of recurrent or persistent NPC from benign lesions, were 100%, 96%, and 97%, respectively. Cases with recurrent or persistent NPC (1.6 to 5.8) had significantly higher SUVs than cases with benign lesions (0.8 to 1.5), The sensitivity, specificity, and accuracy of CT for detecting recurrent or persistent NPC were 72%, 88%, and 83%, respectively. Conclusion: FDG-PET is a better tool than CT for the detection of recurrent or persistent NPC, Either visual interpretation or SUV can be used to differentiate benign lesions from recurrent or persistent NPC. (C) 1998 by American Society of Clinical Oncology.
引用
收藏
页码:3550 / 3555
页数:6
相关论文
共 35 条
[1]   DISTANT METASTASES OF NASOPHARYNGEAL CARCINOMA - A STUDY OF 256 MALE-PATIENTS [J].
AHMAD, A ;
STEFANI, S .
JOURNAL OF SURGICAL ONCOLOGY, 1986, 33 (03) :194-197
[2]   Recurrence of head and neck cancer after surgery or irradiation: Prospective comparison of 2-deoxy-2-[F-18]fluoro-D-glucose PET and MR imaging diagnoses [J].
Anzai, Y ;
Carroll, WR ;
Quint, DJ ;
Bradford, CR ;
Minoshima, S ;
Wolf, GT ;
Wahl, RL .
RADIOLOGY, 1996, 200 (01) :135-141
[3]  
BRONSTEIN AD, 1989, AM J NEURORADIOL, V10, P171
[4]   Detection of recurrent nasopharyngeal carcinoma: MR imaging versus CT [J].
Chong, VFH ;
Fan, YF .
RADIOLOGY, 1997, 202 (02) :463-470
[5]   PET and [F-18]-FDG in oncology: A clinical update [J].
Conti, PS ;
Lilien, DL ;
Hawley, K ;
Keppler, J ;
Grafton, ST ;
Bading, JR .
NUCLEAR MEDICINE AND BIOLOGY, 1996, 23 (06) :717-735
[6]   THE NECK AFTER TOTAL LARYNGECTOMY - CT STUDY [J].
DISANTIS, DJ ;
BALFE, DM ;
HAYDEN, RE ;
SAGEL, SS ;
SESSIONS, D ;
LEE, JKT .
RADIOLOGY, 1984, 153 (03) :713-717
[7]   DISTINGUISHING TUMOR RECURRENCE FROM IRRADIATION SEQUELAE WITH POSITRON EMISSION TOMOGRAPHY IN PATIENTS TREATED FOR LARYNX CANCER [J].
GREVEN, KM ;
WILLIAMS, DW ;
KEYES, JW ;
MCGUIRT, WF ;
HARKNESS, BA ;
WATSON, NE ;
RABEN, M ;
FRAZIER, LC ;
GEISINGER, KR ;
CAPPELLARI, JO .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1994, 29 (04) :841-845
[8]  
GREVEN KM, 1994, CANCER, V74, P1355, DOI 10.1002/1097-0142(19940815)74:4<1355::AID-CNCR2820740428>3.0.CO
[9]  
2-I
[10]  
HABERKORN U, 1991, J NUCL MED, V32, P1485