Biomaterials for the Feeder-Free Culture of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

被引：83

作者：

Higuchi, Akon ^{[1
,2
,3
]}

Ling, Qing-Dong ^{[3
,4
]}

Ko, Yi-An ^{[4
]}

Chang, Yung ^{[5
]}

Umezawa, Akihiro ^{[2
]}

机构：

[1] Natl Cent Univ, Dept Chem & Mat Engn, Tao Yuan 32001, Taiwan

[2] Natl Res Inst Child Hlth & Dev, Dept Reprod, Setagaya Ku, Tokyo 1578535, Japan

[3] Cathay Gen Hosp, Cathay Med Res Inst, New Taipei City, Taiwan

[4] Natl Cent Univ, Inst Syst Biol & Bioinformat, Tao Yuan 32001, Taiwan

[5] Chung Yuan Christian Univ, Dept Chem Engn, R&D Ctr Membrane Technol, Tao Yuan 320, Taiwan

来源：

CHEMICAL REVIEWS | 2011年 / 111卷 / 05期

关键词：

PROLONGED UNDIFFERENTIATED GROWTH; HUMAN BONE-MARROW; SERUM-FREE MEDIUM; HUMAN ES CELLS; EXTRACELLULAR-MATRIX; SELF-RENEWAL; MAINTAIN PLURIPOTENCY; CONDITIONED MEDIUM; DEFINED CONDITIONS; HUMAN FIBROBLASTS;

D O I：

10.1021/cr1003612

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

A scientific review presents biomaterials for the feeder-free culture of human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC). Tissue-specific stem cell niches provide crucial cell-cell contacts and paracrine signaling. The extracellular matrix ECM) keeps stem cells in the niche and serves to initiate signal transduction, while locally concentrated glycosaminoglycans (GAGs) provide soluble growth factors or cytokines. It will be highly beneficial to design, construct, and reproduce the microenvironment and niche of pluripotent stem cells in vitro with biomacromolecules and synthetic polymers. Culture materials derived from biomacromolecules and synthetic polymers have been used to support the propagation of hESCs and human iPSCs while maintaining their pluripotency.

引用

页码：3021 / 3035

页数：15

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