How tumor cells make use of CD44

被引：38

作者：

Herrlich, P

Sleeman, J

Wainwright, D

König, H

Sharman, L

Hilberg, F

Ponta, H

机构：

[1] Forschungszentrum Karlsruhe, Inst Genet, D-76021 Karlsruhe, Germany

[2] Fa Bender & Co GMBH, A-1121 Vienna, Austria

来源：

CELL ADHESION AND COMMUNICATION | 1998年 / 6卷 / 2-3期

关键词：

limb formation; growth factor presentation; CD44; variants; tumor metastasis;

D O I：

10.3109/15419069809004470

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A variant of CD44 containing exon v3 sequences is expressed in the apical ectodermal ridge of the limb bud during embryogenesis. This variant is modified by heparan sulfate moieties and acts as low affinity receptor for FGFs. These FGFs are presented by CD44 to mesenchymal cells which induces their proliferation and limb outgrowth. We suggest that a similar growth factor presentation mechanism accounts for the function of CD44 variants on metastasizing tumor cells.

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页码：141 / 147

页数：7

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