Disruption of calcium homeostasis and arrhythmogenesis induced by mutations in the cardiac ryanodine receptor and calsequestrin

被引：45

作者：

Liu, Nian ^{[1
]}

Priori, Silvia G. ^{[1
,2
]}

机构：

[1] Fondaz Salvatore Maugeri, I-27100 Pavia, Italy

[2] Univ Pavia, Dept Cardiol, I-27100 Pavia, Italy

来源：

CARDIOVASCULAR RESEARCH | 2008年 / 77卷 / 02期

关键词：

ventricular arrhythmias; SR (function); sudden death; e-c coupling; calcium (cellular);

D O I：

10.1093/cvr/cvm004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Development of cardiac arrhythmias in several degenerative cardiac disorders such as heart failure is precipitated by abnormalities in intracellular calcium regulation. Recently, the identification of mutations in proteins responsible for the control of intracellular calcium has been associated with an inherited arrhythmogenic syndrome called catecholaminergic polymorphic ventricular tachycardia (CPVT). Here, we review the current knowledge about the molecular pathophysiology of CPVT and we discuss some potentially innovative strategies for controlling calcium-handling abnormalities in CPVT that may provide novel therapeutic options for affected patients.

引用

收藏

页码：293 / 301

页数：9

相关论文

共 59 条

[1] Cardiac excitation-contraction coupling [J].

Bers, DM .

NATURE, 2002, 415 (6868) :198-205

[2] Macromolecular complexes regulating cardiac ryanodine receptor function [J].

Bers, DM .

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2004, 37 (02) :417-429

[3]

Bers Donald M, 2006, Biochem J, V396, pe1

[4] Bidirectional ventricular tachycardia and fibrillation elicited in a knock-in mouse model carrier of a mutation in the cardiac ryanodine receptor [J].

Cerrone, M ;

Colombi, B ;

Santoro, M ;

di Barletta, MR ;

Scelsi, M ;

Villani, L ;

Napolitano, C ;

Priori, SG .

CIRCULATION RESEARCH, 2005, 96 (10) :E77-E82

[5]

Cerrone M, 2006, CIRCULATION, V114, P267

[6] β-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase [J].

Curran, Jerald ;

Hinton, Mark J. ;

Rios, Eduardo ;

Bers, Donald M. ;

Shannon, Thomas R. .

CIRCULATION RESEARCH, 2007, 100 (03) :391-398

[7] Clinical phenotype and functional characterization of CASQ2 mutations associated with catecholaminergic polymorphic ventricular tachycardia [J].

di Barletta, Marina Raffaele ;

Viatchenko-Karpinski, Serge ;

Nori, Alessandra ;

Memmi, Mirella ;

Terentyev, Dmitry ;

Turcato, Federica ;

Valle, Giorgia ;

Rizzi, Nicoletta ;

Napolitano, Carlo ;

Gyorke, Sandor ;

Volpe, Pompeo ;

Priori, Silvia G. .

CIRCULATION, 2006, 114 (10) :1012-1019

[8] Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans [J].

Díaz, ME ;

O'Neill, SC ;

Eisner, DA .

CIRCULATION RESEARCH, 2004, 94 (05) :650-656

[9] A mutation in calsequestrin, CASQ2 D307H, impairs sarcoplasmic reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice [J].

Dirksen, Wessel P. ;

Lacombe, Veronique A. ;

Chi, Mei ;

Kalyanasundaram, Anuradha ;

Viatchenko-Karpinski, Serge ;

Terentyev, Dmitry ;

Zhou, Zhixiang ;

Vedamoorthyrao, Srikanth ;

Li, Ning ;

Chiamvimonvat, Nipavan ;

Carnes, Cynthia A. ;

Franzini-Armstrong, Clara ;

Gyorke, Sandor ;

Periasamy, Muthu .

CARDIOVASCULAR RESEARCH, 2007, 75 (01) :69-78

[10]

FABIATO A, 1983, AM J PHYSIOL, V245, pC1

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