Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus

被引：717

作者：

Dejnirattisai, Wanwisa ^{[1
]}

Supasa, Piyada ^{[1
,2
,3
]}

Wongwiwat, Wiyada ^{[1
]}

Rouvinski, Alexander ^{[4
,5
]}

Barba-Spaeth, Giovanna ^{[4
,5
]}

Duangchinda, Thaneeya ^{[6
]}

Sakuntabhai, Anavaj ^{[7
,8
]}

Cao-Lormeau, Van-Mai ^{[9
]}

Malasit, Prida ^{[6
]}

Rey, Felix A. ^{[4
,5
]}

Mongkolsapaya, Juthathip ^{[1
,2
]}

Screaton, Gavin R. ^{[1
]}

机构：

[1] Imperial Coll London, Dept Med, Div Immunol & Inflammat, Hammersmith Campus, London, England

[2] Mahidol Univ, Siriraj Hosp, Dengue Hemorrhag Fever Res Unit, Off Res & Dev,Fac Med, Bangkok, Thailand

[3] Mahidol Univ, Siriraj Hosp, Dept Immunol, Fac Med,Grad Program Immunol, Bangkok, Thailand

[4] Inst Pasteur, Dept Virol, Unite Virol Struct, Paris, France

[5] CNRS UMR 3569 Virol, Paris, France

[6] Natl Sci & Technol Dev Agcy, Med Biotechnol Unit, Natl Ctr Genet Engn & Biotechnol, Pathum Thani, Thailand

[7] Inst Pasteur, Funct Genet Infect Dis Unit, Paris, France

[8] CNRS URA3012, Paris, France

[9] Inst Louis Malarde, Unit Emerging Infect Dis, Papeete, France

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 09期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

NEUTRALIZING ANTIBODIES; CHIKUNGUNYA VIRUS; OUTBREAK; BRAZIL; BRAIN;

D O I：

10.1038/ni.3515

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Zika virus (ZIKV) was discovered in 1947 and was thought to lead to relatively mild disease. The recent explosive outbreak of ZIKV in South America has led to widespread concern, with reports of neurological sequelae ranging from Guillain Barre syndrome to microcephaly. ZIKV infection has occurred in areas previously exposed to dengue virus (DENV), a flavivirus closely related to ZIKV. Here we investigated the serological cross-reaction between the two viruses. Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZIKV infection. Using a panel of human monoclonal antibodies (mAbs) to DENV, we showed that most antibodies that reacted to DENV envelope protein also reacted to ZIKV. Antibodies to linear epitopes, including the immunodominant fusion-loop epitope, were able to bind ZIKV but were unable to neutralize the virus and instead promoted ADE. Our data indicate that immunity to DENV might drive greater ZIKV replication and have clear implications for disease pathogenesis and future vaccine programs for ZIKV and DENV.

引用

页码：1102 / 1108

页数：7

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