A study of novel antiallergic agents with eosinophilic infiltration inhibiting action

被引：4

作者：

Kawasaki, N

Miyataka, H

Matsumoto, H

Yamashita, N

Sakane, T

Mizushima, Y

Satoh, T

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Tokushima 7708514, Japan

[2] St Marianna Univ, Sch Med, Inst Med Sci, Kawasaki, Kanagawa 2168511, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(98)00676-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The antiallergic action of a series of novel mono-O-substituted trimethylhydroquinones was investigated. Among this series of the compounds, 4-[4-[4-(diphenylmethyl)-1-piperazinyl]butoxy]-2,3,6-trimethylphenol (compound 3) showed a potent antihistaminic action (pA(2)=7.11) and an antiasthmatic action (100 mg/kg p. o.) on sensitized guinea pigs. Moreover, this compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized mice (100 mg/kg p. o.). (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：19 / 24

页数：6

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