Novel water-soluble and pH-responsive anticancer drug nanocarriers: Doxorubicin-PAMAM dendrimer conjugates attached to superparamagnetic iron oxide nanoparticles (IONPs)

被引：93

作者：

Chang, Yulei ^{[1
]}

Meng, Xinlei ^{[1
]}

Zhao, Yili ^{[1
]}

Li, Kun ^{[1
]}

Zhao, Bao ^{[1
]}

Zhu, Ming ^{[1
]}

Li, Yapeng ^{[1
]}

Chen, Xuesi ^{[2
]}

Wang, Jingyuan ^{[1
]}

机构：

[1] Jilin Univ, Dept Chem, Alan G MacDiarmid Inst, Changchun 130023, Peoples R China

[2] Chinese Acad Sci, Chang Chun Inst Appl Chem, Changchun 130022, Peoples R China

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2011年 / 363卷 / 01期

关键词：

Dendrimers; PAMAM; Doxorubicin; DOX; Iron oxide NPs; RESONANCE CONTRAST AGENTS; TUMOR; MICELLES; DELIVERY;

D O I：

10.1016/j.jcis.2011.06.086

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070305 [高分子化学与物理];

摘要：

PH-responsive drug release system based on the conjugates of PAMAM dendrimers-doxorubicin (PAMAM-DOX) and superparamagnetic iron oxide (Fe3O4) nanoparticles (IONPs) has been constructed and characterized. The IONPs were stabilized by mPEG-G2.5 PAMAM dendrimers. The anticancer drug DOX was conjugated to the dendrimer segments of amino-stabilized IONPs using hydrazine as the linker via hydrazone bonds, which is acid cleavable and can be used as an ideal pH-responsive drug release system. The drug release profiles of DOX-PAMAM dendrimer conjugates were studied at pH 5.0 and 7.4. The results showed that the hydrolytic release profile can be obtained only at the condition of lysosomal pH (pH = 5.0), and IONPs participated in carrying DOX to the tumor by the Enhanced Permeability and Retention (EPR) effect. These novel DOX-conjugated IONPs have the potential to enhance the effect of MRI contrast and cancer therapy in the course of delivering anticancer drugs to their target sites. Although the dendrimer-DOX-coated IONPs do not have any targeting ligands attached on their surface, they are potentially useful for cancer diagnosis in vivo. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：403 / 409

页数：7

共 31 条

[1]

Dendrisomes: cationic lipidic dendron vesicular assemblies [J].