Mitotic mechanics: the auroras come into view

被引：249

作者：

Andrews, PD ^{[1
]}

Knatko, E ^{[1
]}

Moore, WJ ^{[1
]}

Swedlow, JR ^{[1
]}

机构：

[1] Univ Dundee, Wellcome Trust Bioctr, Div Gene Express & Regulat, Dundee DD1 5EH, Scotland

来源：

CURRENT OPINION IN CELL BIOLOGY | 2003年 / 15卷 / 06期

关键词：

D O I：

10.1016/j.ceb.2003.10.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Aurora kinases have recently taken centre stage in the regulation of key cell cycle processes. Aurora A is emerging as a critical regulator of centrosome and spindle function. Aurora B mediates chromosome segregation by ensuring proper biorientation of sister chromatids, possibly through the regulation of microtubule dynamics. This enzyme also functions in cytokinesis apparently by interacting with a critical GTPase and a kinesin-like protein. Recent work on both kinases has revealed functional links between Aurora kinase activity and the mechanics of cell division.

引用

页码：672 / 683

页数：12

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