Functional significance of alterations in cardiac contractile protein isoforms

被引：7

作者：

Kitsis, RN

Scheuer, J

机构：

[1] ALBERT EINSTEIN COLL MED,DEPT CELL BIOL,BRONX,NY 10467

[2] ALBERT EINSTEIN COLL MED,DEPT PHYSIOL & BIOPHYS,BRONX,NY 10467

来源：

CLINICAL CARDIOLOGY | 1996年 / 19卷 / 01期

关键词：

contractile proteins; heart failure; cardiac function;

D O I：

10.1002/clc.4960190105

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Multiple closely related, yet distinct, isoforms ex ist for each of the cardiac contractile proteins. The isoform composition of the heart changes in response to developmental and physiologic cues. This paper reviews the molecular basis for cardiac contractile protein isoform diversity and the functional consequences of isoform shifts.

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页码：9 / 18

页数：10

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